A generalizable machine learning framework for classifying DNA repair defects using ctDNA exomes Abstract Specific classes of DNA damage repair (DDR) defect can drive sensitivity to emerging therapies for metastatic prostate cancer. However, biomarker approaches based...

Combined low-pass whole genome and targeted sequencing in liquid biopsies for pediatric solid tumors Abstract We designed a liquid biopsy (LB) platform employing low-pass whole genome sequencing (LP-WGS) and targeted sequencing of cell-free (cf) DNA from plasma to...

Although cancer treatments have improved drastically over the past decade, many cancers can adapt to evade therapeutic drugs. To develop more effective cancer treatments, researchers strive to understand how cancers evolve and interact with other cells in their...